CNIO_EVENTOS

Molecular chaperones play a crucial role in maintaining protein folding, stability, and function in both normal and disease states, including cancer. Despite significant advances, our understanding of the precise molecular mechanisms underlying chaperone function and their role in cancer development remains incomplete. This conference will focus on recent progress in elucidating the structure and function of molecular chaperones, particularly HSP90, using model organisms. Additionally, we will explore the role of chaperones in networks with other proteins in cancer phenotypes, how chaperones support cancer evolution, and approaches to better target chaperones for cancer treatment. By bringing together researchers and clinicians from diverse disciplines, we aim to foster collaboration and advance our understanding of the critical role of chaperones in cancer biology.

Topics to be covered:

• Folding, misfolding, and aggregation.
• UPR and stress mechanisms
• Prefoldins and chaperones in cancer
• Targeting chaperones: chaperonotherapy

FECHA LÍMITE DE INSCRIPCIÓN 27/05/2024
FECHA LÍMITE DE ENVÍO DE RESUMEN 06/05/2024
PRECIO 200 Euro Students and CNIO staff; 400 Euro Post-docs and Academia; 600 Euro Industry.

Metastasis is the main driving force for cancer-associated lethality as they are more difficult to treat than primary tumors. The exponential increase in heterogeneity throughout the metastatic cascade and the underlying biology that involves the generation of novel ecosystems incorporating resident and peripheral components of the microenvironment might explain the increased ability to resist therapies. The CNIO Frontier meeting will provide the most up-to-date perspective on metastasis including the best ways to model metastasis, embrace its heterogeneity, prevent metastases from happening, exploit organ-specific survival mechanism of cancer cells among other key topics. These novel research findings will be contributed by leaders in the field, which will make the CNIO Frontier Meeting on Metastasis the most relevant cancer research forum of the year.

Topics to be covered:

• Modelling Evolution of Metastasis
• Non-Genetic Adaptation in Metastasis (Metabolism, Epigenetics and Stress)
• Microorganismal Influence on Metastasis
• Anti-Metastasis Therapies and Clinical
• Influence of Microenvironment in Metastasis
• CTCS/ DTC/ CTDNA: New Technologies and Implications
• Neurobiology of Metastasis

Abstracts:

Abstract submission deadline September 25, 2023
Abstracts must be submitted online when you register.

Top scoring abstracts will be selected for short talks in the main programme
Abstract Title (max. 50 words) / Abstract Authors (max. 100 words) / Abstract Centres/Organisations (max. 100 words) / Abstract (max. 450 words including references)

Registration and Payment:

200 Euro Students and CNIO staff; 400 Euro Post-docs and Academia; 600 Euro Industry
Register now

The 3D folding of chromatin within the nucleus determines the framework in which all processes of
genome dynamics occur and has attracted extraordinary attention in the last few years, fundamentally with
the development of genome-wide chromosome-conformation-capture techniques, which have radically
changed our understanding of how the genome is spatially organised in a dynamic fashion. The most
illustrative example for this is perhaps the regulation of gene expression, which is now unconceivable to
understand without a three-dimensional context of controlled chromatin interactions. The connections
between 3D genome organisation and the processes that signal and repair DNA damage in order to
maintain genome integrity are, however, only now starting to emerge, and proving fundamental to
understand the endogenous sources of DNA breaks and chromosomal rearrangement events that drive
cancer onset and progression. In this meeting we aim at bringing together world-leading researchers in
both fields, 3D genome organisation and the DNA-damage response, in order to provide an ideal setting
to bridge the gap between these two fundamental aspects of genome dynamics.

Topics to be covered:

• Fundamental principles of genome organisation
• SMC complexes in genome organisation and dynamics
• Genome organisation and the DNA-damage response
• Genome organisation and replicative stress
• Genome organisation in health and disease

Abstracts:

Abstract submission deadline April 20, 2023. Abstracts must be submitted online when you register.
Registration Submission deadline May 8, 2023

Top scoring abstracts will be selected for short talks in the main programme. Abstract Title (max. 50
words) / Abstract Authors (max. 100 words) / Abstract Centres/Organisations (max. 100 words) / Abstract
(max. 450 words including references)

Registration and Payment: 200 Euro Students and CNIO staff; 400 Euro Post-docs and Academia; 600
Euro Industry. Register now!